| 发明名称 | GH61 glycoside hydrolase protein variants and cofactors that enhance GH61 activity | ||
| 摘要 | The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes, thereby increasing the yield of fermentable sugars obtained by saccharification of biomass. In some embodiments, sugars obtained from saccharification are fermented to produce numerous end-products, including but not limited to alcohol. | ||
| 申请公布号 | US8877474(B2) | 申请公布日期 | 2014.11.04 |
| 申请号 | US201213592024 | 申请日期 | 2012.08.22 |
| 申请人 | Codexis, Inc. | 发明人 | Yang Jie;Zhang Xiyun;Yoon Jungjoo;Rao Kripa;Grate John H.;Elgart David;Baidyaroy Dipnath |
| 分类号 | C12N9/96;C12N9/16;C12N9/20;C12N15/00;C12N1/00;C07H21/04;C12P19/14;C12N9/30;C12P7/10;C12N9/42 | 主分类号 | C12N9/96 |
| 代理机构 | Codexis, Inc. | 代理人 | Codexis, Inc. |
| 主权项 | 1. A glycoside hydrolase 61 (GH61) variant protein comprising an amino acid sequence that is at least at least 90%, identical to SEQ ID NO:2 or a fragment of SEQ ID NO:2 having GH61 activity, wherein the amino acid sequence of the variant protein has one or more amino acid substitutions with respect to SEQ ID NO:2 or said fragment. | ||
| 地址 | Redwood City CA US | ||