| 发明名称 |
USE OF THE CD2 SIGNALING DOMAIN IN SECOND-GENERATION CHIMERIC ANTIGEN RECEPTORS |
| 摘要 |
<p>The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.</p> |
| 申请公布号 |
KR20140127829(A) |
申请公布日期 |
2014.11.04 |
| 申请号 |
KR20147023594 |
申请日期 |
2013.02.22 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
JUNE CARL H.;SCHOLLER JOHN;POSEY AVERY D. |
| 分类号 |
C12N15/12;C07K14/705;C12N5/0783 |
主分类号 |
C12N15/12 |
| 代理机构 |
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