发明名称 |
Monoclonal antibodies to fibrin |
摘要 |
The present invention provides an isolated antibody that binds a fibrin or fibrinogen γC domain. In various aspects, the antibody inhibits microglial adhesion to the fibrin or fibrinogen γC domain, inhibits Mac-1 binding to the fibrin or fibrinogen γC domain, and/or suppresses clinical symptoms of Experimental Autoimmune Encephalomyelitis (EAE). Various methods of using the antibodies, pharmaceutical compositions, kits, vectors, cells comprising the vectors, and antibody generating methods are provided. |
申请公布号 |
US8877195(B2) |
申请公布日期 |
2014.11.04 |
申请号 |
US201213425020 |
申请日期 |
2012.03.20 |
申请人 |
The Regents of the University of California |
发明人 |
Akassoglou Katerina |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
Sutherland Asbill & Brennan LLP |
代理人 |
Sutherland Asbill & Brennan LLP |
主权项 |
1. An isolated antibody that binds human fibrin or fibrinogen γC domain, and inhibits Mac-1 binding to fibrin or fibrinogen γC domain, wherein the antibody light chain comprises three complementarity determining regions comprising the amino acid sequences of RSSKSLLHSSGITYLS (SEQ ID NO:2), QMSNLAS (SEQ ID NO:3), and AQNLELPLT (SEQ ID NO:4), respectively, and the antibody heavy chain comprises three complementarity determining regions comprising the amino acid sequences of GYTFTSYWIH (SEQ ID NO:6), LIDPSDSYTNYNQKFRG (SEQ ID NO:7), and SDPTGC (SEQ ID NO:8), respectively. |
地址 |
Oakland CA US |