Contrast agents anchored by thiols on nanoparticles

摘要

The present invention is directed toward a multivalent product including a nanoparticle with a metal, metal alloy, or metal oxide core, a plurality of non-polymerizing ligands bound to the nanoparticle, and a plurality of paramagnetic ions coupled to the nanoparticle by the ligands. Methods of making and using the multivalent product are also disclosed.

主权项

1. A multivalent product comprising:
a nanoparticle comprising a metal, metal alloy, or metal oxide core; a plurality of ligands bound to the nanoparticle, said ligands selected from the group consisting of cysteine N,N′-tetraacetic acid; diethylenetriaminepentaacetic acid-L-Cys; diethylenetriaminepentaacetic acid lipoic acid; 1,4,7,10-tetracarboxymethyl-1,4,7,10-tetraazacyclododecane-L-Cys; 1,4,7,10-tetracarboxymethyl-1,4,7,10-tetraazacyclododecane-lipoic acid; 2,2′-((2-((1-carboxy-3-mercaptopropyl)(carboxymethyl)amino)ethyl)azanediyl)diacetic acid;and mixtures thereof; anda plurality of paramagnetic ions coupled to the nanoparticle by the ligands.