Sprayable gel wound dressing

摘要

A sprayable hydrogel wound dressing composed of an aqueous solution of neutralized Carbopol and silver hydrosol of silver nanoparticles electrolytically formed from silver metal without the use or inclusion of organic materials. The hydrogel is sprayed with a physical barrier sprayer system which separates the hydrogel from the propellant. The hydrogel is thixotropic/shear thinning so that the viscosity of the hydrogel is sufficient reduced in the sprayer to allow spray formation and regains sufficient viscosity to resist running when deposited on a vertical surface.

主权项

1. A nanoparticle silver hydrogel sprayer system comprising:
a pressurized bag on valve sprayer comprising a pressurized container, a flexible bag within the pressurized container, and a valve operable to connect an inlet inside of the flexible bag with an outlet outside of the pressurized container; an aqueous thixotropic/shear thinning hydrogel having an initial viscosity of about 8,000 to 10,000 cP and containing between 1-200 ppm total silver in the form of metallic silver nanoparticles wherein said silver nanoparticles have a surface of silver oxide and wherein said silver nanoparticles are produced electrolytically from silver metal without using any organic material, said hydrogel disposed inside of the flexible bag without propellant; and a nozzle in fluidic communication with the outlet so that operation of the valve allows said hydrogel to be forced through the valve where shear forces temporarily reduce said hydrogel's viscosity from the initial viscosity thereby allowing said hydrogel to be dispersed by the nozzle as a mist or spray of fine droplets which then deposits on a surface to form a layer of hydrogel having a final viscosity about equal to the initial viscosity, said layer resistant to running or sagging.