| 发明名称 |
Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α<sub>1</sub>-adrenoceptor agonists |
| 摘要 |
The present invention is directed to the treatment of skin erythema as exhibited in rosacea and other conditions characterized by increased erythema (redness) of the skin. These conditions exhibit dilation of blood vessels due to a cutaneous vascular hyper-reactivity. In particular, the present invention is directed to a novel composition and method for the treatment of skin erythema using α1-adrenergic receptor (α1-adrenoceptor) agonists incorporated into cosmetic, pharmacological or dermatological compositions for topical application to the skin. |
| 申请公布号 |
US8877793(B2) |
申请公布日期 |
2014.11.04 |
| 申请号 |
US201012901911 |
申请日期 |
2010.10.11 |
| 申请人 |
Allergan, Inc. |
发明人 |
Shanler Stuart D.;Ondo Andrew |
| 分类号 |
A01N43/50;A61K31/415;A01N33/02;A61K31/135;C07D233/00;C07D233/02;A61Q19/00;A61Q19/02;A61K8/49;A61K45/06;A61K31/4174;A61K31/137;A61K31/4164 |
主分类号 |
A01N43/50 |
| 代理机构 |
|
代理人 |
Banerjee Krishna |
| 主权项 |
1. A method of treating telangiectasias of rosacea in a subject comprising administering topically to the skin of said subject in need thereof a composition comprising a therapeutically effective amount of an α1-adrenoreceptor agonist as the sole active agent for decreasing said telangiectasias of rosacea, wherein said α1-adrenoreceptor agonist is selected from oxymetazoline, oxymetazoline hydrochloride, tetrahydrozoline, tetrahydrozoline hydrochloride, naphazoline, naphazoline hydrochloride, xylometazoline, and xylometazoline hydrochloride. |
| 地址 |
Irvine CA US |
