Substituted pyridopyrimidine compounds and their use as FLT3 inhibitors

摘要

Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I).;

主权项

1. A compound represented by Formula (I): wherein: R1 is aryl, arylalkyl, C5-C6cycloalkyl or C5-C6cycloalkyl methyl optionally substituted with R3; R3 is independently fluoro, chloro, bromo, iodo, C1-C6alkyl, or CF3; X is F, Cl, Br, I, CH3, or CF3; Y is chloro, bromo, iodo, —C1-C3alkyl or phenyl; R2 is C4-C7heterocycloalkyl, wherein the C4-C7heterocycloalkyl has 1 or nitrogen atoms in the C4-C7 heterocycloalkyl ring, and is substituted at nitrogen with R5; and R5 is C1-C3alkyl or C(O)C1-C3alkyl, wherein the C1-C3alkyl group is optionally substituted with 1-3 fluorine atoms; or a pharmaceutically acceptable salt thereof.