Surgical sutures incorporated with stem cells or other bioactive materials

摘要

Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.

主权项

1. A surgical suture comprising:
(a) a porous core comprising a multifilament or a matrix of braided or woven filaments comprising a plurality of interstices disposed between the filaments; and (b) a sheath which is exterior to the porous core and comprises one or more concentric layers; wherein a concentration of biological cells are retained in the plurality of interstices; and wherein the sheath controls the migration of the biological cells from the plurality of interstices to an exterior of the sheath.