PROCESS FOR PRODUCTION OF RADIOACTIVE FLUORINE-LABELED ORGANIC COMPOUND

摘要

Provided is a process for production of [18F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for production of a radioactive fluorine-labeled organic compound, which comprises: a de-esterification step of retaining, in a reverse-phase column, a compound represented by Formula (1): (see formula 1) wherein R1 is a linear or branched C1-C10 alkyl chain or an aromatic substituent; and R2 is a protecting group; charging the column with an alkaline solution to de-esterify the compound, and subsequently discharging the alkaline solution from the column to obtain a compound represented by Formula (2): (see formula 2) wherein X is sodium or potassium; and a deprotection step of deprotecting the amino-protecting group of the compound obtained in the de-esterification step to obtain a compound represented by Formula (3): (see formula 3)