Compositions and methods for inhibition of cathepsins

摘要

This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.;

主权项

1. A compound of formula I:or a solvate or pharmaceutically acceptable salt thereof, wherein
X is selected from the group consisting of C(═O), CH(OR6) and n is 0, 1, 2 or 3; m is 0, 1, 2 or 3; p is 0, 1, 2 or 3; R1 is hydrogen, C1-C3 alkyl, aryl and arylalkyl; R2 is hydrogen or C1-C3 alkyl; each R3 and R5 independently is selected from the group consisting of hydroxyl, C1-C3 alkyl, C1-C2 alkoxy, fluoro, and chloro; each R4 independently is selected from the group consisting of hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, halo, amino, nitro, nitroso and acyl; and R6 is selected from the group consisting of hydrogen and methyl.