Compositions for delivery of insoluble agents

摘要

Compositions and methods of making the same for in vivo delivery of lixivaptan to a subject in need thereof are described. The composition includes a substantially water-insoluble pharmacologically active agent (e.g., lixivaptan) and a substantially water-insoluble matrix forming material (e.g., a Vitamin E semi-ester), wherein the pharmacologically active agent is dispersed in said matrix forming material, and wherein the composition delivers said substantially water-insoluble pharmacologically active agent upon exposure to physiological medium.

主权项

1. A pharmaceutical composition comprising a single oral dosage form including an oil-free and substantially water-free solid dispersion, the dispersion including a therapeutically effective amount of lixivaptan and 50% or more by weight of a vitamin E semi-ester.