| 发明名称 | Targeting agent to newly formed blood vessels | ||
| 摘要 | It is an object of the present invention to provide a targeting agent that enables drug delivery to a neovascular site and the imaging of such a neovascular site, utilizing the effect of the agent to accumulate in the neovascular site. The present invention provides a targeting agent to a neovascular site, which comprises a gelatin-like protein. | ||
| 申请公布号 | US8877158(B2) | 申请公布日期 | 2014.11.04 |
| 申请号 | US201013377788 | 申请日期 | 2010.06.11 |
| 申请人 | FUJIFILM Corporation;Kyoto University | 发明人 | Nakamura Kentaro;Tabata Yasuhiko |
| 分类号 | A61K51/00;A61M36/14;A61K49/00;A61B5/00;A61B5/055;A61K49/04;A61K38/39;A01N25/00;A61K51/08;C07K14/78;A61K47/48 | 主分类号 | A61K51/00 |
| 代理机构 | Sughrue Mion, PLLC | 代理人 | Sughrue Mion, PLLC |
| 主权项 | 1. A method for targeting a substance to a neovascular site, which comprises administering a recombinant gelatin to a subject, wherein the recombinant gelatin has the following (1) or (2): (1) the amino acid sequence shown in SEQ ID NO: 1; or (2) an amino acid sequence having 80% or more percent identity to the amino acid sequence shown in SEQ ID NO: 1 and having an action to accumulate in newly formed blood vessels, and wherein the recombinant gelatin is used in combination with a labeled probe, the labeled probe being selected from the group consisting of a fluorescent dye, a radioisotope, a nuclide used for PET, a nuclide used for SPECT, an MRI contrast medium, a CT contrast medium, and a magnetic material. | ||
| 地址 | Tokyo JP | ||