Protection against skin diseases by aurin tricarboxylic acid and its derivatives

摘要

This invention describes a method of preventing and treating inflammatory skin diseases by topical application of aurin tricarboxylic acid and its derivatives. Such diseases are characterized by immune attack, especially involving aberrant complement activation. The diseases include, but are not limited to, androgenetic alopecia (baldness), seborrheic dermatitis/dandruff, allergic dermatitis, primary cicatricial alopecia, pemphigus, psoriasis, discoid lupus erythematosis, and dermatitus herpetiformis.

主权项

1. A method of treating skin diseases and disorders in a human or animal in need thereof comprising inhibiting complement activation by topical application of a therapeutically effective amount of aurin tricarboxylic acid (ATA), aurin quadracarboxylic acid (AQA), aurin hexacarboxylic acid (AHA), or a combination thereof, as an active agent for treatment of the skin diseases and disorders selected from the group consisting of androgenetic alopecia, alopecia areata, seborrheic dermatitis or dandruff, irritant dermatitis, primary cicatricial alopecia, pemphigus, psoriasis, discoid lupus erythematosis and dermatitis herpetiformis, wherein the active agent excludes any components greater than 1 kDa.