Degradable hydrophilic block copolymers with improved biocompatibility for soft tissue regeneration

摘要

The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O—(CHR1CHR2O)n—B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [—(CHR1CHR2O)—] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.

主权项

1. A biodegradable, porous material comprising a polymer of the general formula
A-O—(CHR1CHR2O)n—B, wherein
A is a poly(lactide-co-glycolide) residue having a molecular weight of at least 4000 g/mol, wherein the molar ratio of (i) lactide units [—CH(CH3)—COO—] to (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue is 70:30 to 10:90 andwherein the molar ratio of (iii) polyalkylene glycol units [—(CHR1CHR2O)—] to the combined amount of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue(s) is at the most 1:9 and,wherein B is either a poly(lactide-co-glycolide) residue as defined for A or is selected from the group consisting of hydrogen, C1-6-alkyl and hydroxy protecting groups,one of R1 and R2 within each —(CHR1CHR2O)— unit is selected from hydrogen and methyl, and the other of R1 and R2 within the same —(CHR1CHR2O)— unit is hydrogen,n represents the average number of —(CHR1CHR2O)— units within a polymer chain and is an integer in the range of 10-1000,the number average molecular weight of the polymer is at least 10,000 g/mol, andwherein the porosity of the material is at least 50%.