| 主权项 |
1. A compound of formula I wherein Ar is selected from a group consisting of phenylene and pyridinylene, which are each optionally substituted with one or two substituents independently selected from F, Cl, —O—CH3 and CH3; R1 independently of one another are selected from a group consisting of halogen, CN, C1-6-alkyl, C3-6-cycloalkyl, —O—(C1-6-alkyl), —S—(C1-3-alkyl), —O—(C3-6-cycloalkyl), —O—(C5-6-cycloalkenyl), —O—(CH2)1-2-(C3-6-cycloalkyl), —O—(C1-3-alkyl)-aryl, —O—CH2—(C2-4-alkenyl), —O—CH2—(C2-4-alkinyl), —O—CH2-tetrahydrofuranyl, —O—CH2-heteroaryl, —O-heterocyclyl, —O-aryl, —O-heteroaryl, —(C═O)—NH-aryl, —NRN1RN2, wherein RN1 is H or C1-3-alkyl, andRN2 is H, C1-4-alkyl, C3-6-cycloalkyl, —CH2—(C3-6-cycloalkyl), heterocyclyl or —CH2-heterocyclyl,or wherein RN1 and RN2 are connected and together with the N-atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, 2,5-dihydro-1H-pyrrolyl, morpholinyl or [1,4]oxazepanyl ring, wherein each of said rings is optionally substitued with one or two F, OH, C1-3-alkyl, —O—C1-3-alkyl or —(C1-3-alkyl)-O—(C1-3-alkyl), said substituents being the same or different,wherein heterocyclyl is tetrahydrofuranyl or tetrahydropyranyl,wherein heteroaryl is selected from the group consisting of pyridinyl, pyrimidinyl, pyridazinyl and pyrazinyl,wherein aryl is selected from the group consisting of phenyl, indanyl and naphthyl,wherein each alkyl is linear or branched and is optionally substituted with 1 to 6 F or with one —OH or —O—(C1-3-alkyl),wherein each cycloalkyl is optionally substituted with 1 to 4 F or with one CN, OH, CH3, CF3 or —SO2—(C1-3-alkyl), and wherein each aryl or heteroaryl is optionally substituted with one or two substituents independently selected from F, Cl, C1-3alkyl or —O—CH3; n is 1, 2 or 3; R2 is H, F, Cl, CN or —O—(C1-3-alkyl); R3 is H or C1-3-alkyl; L is straight-chain C1-3-alkylene, which is optionally substituted with one or two C1-3-alkyl groups; and T is selected from a group consisting of H,
linear or branched C1-6-alkyl which is optionally substituted with one to six F, with one CN, OH, —O—CH3 or —O—C(═O)—CH3, or with a heteroaryl group preferably selected from the group consisting of: oxazolyl, thiazolyl, pyrrolyl, isoxazolyl, pyrimidinyl and pyrazinyl,
wherein each of said heteroaryl groups is optionally substituted with one or two substituents, which are independently of each other selected from the group consisting of C1-3-alkyl, —(C1-3-alkyl)-O—CH3 and —NH—(C═O)—(C1-3-alkyl);(C2-4-alkenyl)-(C3-7-cycloalkyl);C3-6-cycloalkyl which is optionally substituted with one or two F, CN, CH3, CF3, OH, —O—(C1-3-alkyl), NH2, —NH—(C═O)CH3, —C(═O)—NH2, —C(═O)—NH(C1-3-alkyl) or —C(═O)—N(C1-3-alkyl)2, wherein the substituents are identical of different;—O—(C1-2-alkyl);tetrahydrofuranyl;—NR4R5, wherein R4 is H or C1-3-alkyl, and R5 is H, C1-3-alkyl, —(C1-3-alkyl)-O—CH3 or a 5-membered heteroaryl group containing 1 to 3 heteroatoms selected independently from O, S, N and NH, wherein said heteroaryl group is optionally substituted with C1-3-alkyl; or wherein R4 and R5 are connected and together with the N to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl ring that is optionally substituted with one or two C1-3-alkyl or with one —NH—(C═O)—CH3;a 5-membered heteroaryl group containing one to three heteroatoms selected independently from O, S, N and NH, which is optionally substituted with one or two substituents selected independently from the group consisting of:Cl, C1-3-alkyl, —NH—C(═O)—(C1-3-alkyl)-O—CH3, NH2, —NH—C(═O)—C1-3-alkyl, —NH—C(═O)—CH2OH, —NH—C(═O)—CH2O—C(═O)CH3, —NH—C(═O)—CH2OCH2-Ph and —O—(C1-2-alkyl), wherein each alkyl group is optionally substituted with one to three F or with one OH;a 6-membered heteroaryl group containing 1 or 2 N, which is optionally substituted with F, CN, —CH3, —C(═O)—NH—(CH3) or —NH—C(═O)—(CH3); andphenyl optionally substituted with F, Cl, CN or —OCH3; or a tautomer or salt thereof. |
