Targeting microRNAs for metabolic disorders

摘要

Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of blood glucose level, the reduction of gluceoneogenesis, the improvement of insulin resistance and the reduction of plasma cholesterol level. In certain embodiments, the methods comprise inhibiting the activity of miR-103. In certain embodiments, the methods comprise inhibiting the activity of miR-107. In certain embodiments, the activity of both miR-103 and miR-107 is inhibited. In certain embodiments, such methods comprise administering a compound comprising an oligonucleotide targeted to a microRNA.

主权项

1. A method of reducing blood glucose in a subject in need thereof comprising administering to the subject a compound comprising modified oligonucleotide having a nucleobase sequence at least 90% complementary to nucleobases 1-21 of SEQ ID NO: 1 (miR-103) or nucleobases 1-21 of SEQ ID NO: 2 (miR-107), wherein the modified oligonucleotide consists of 12 to 30 linked nucleosides.