| 发明名称 | Benzimidazole compound and pharmaceutical use thereof | ||
| 摘要 | Provided is an ORL-1 receptor agonist having improved bioavailability based on superior metabolic stability and strong and high selectivity, as compared to conventional compounds. A compound represented by the formula (I); wherein each symbol is as defined in the claims. | ||
| 申请公布号 | US8877779(B2) | 申请公布日期 | 2014.11.04 |
| 申请号 | US200812449874 | 申请日期 | 2008.02.28 |
| 申请人 | Mitsubishi Tanabe Pharma Corporation | 发明人 | Nakano Masakazu;Minoguchi Masanori;Hanano Tokushi;Ono Shin-ichiro;Horiuchi Hideki;Teshima Koji |
| 分类号 | A61K31/445;C07D401/04;C07D417/14;C07D405/14;C07D471/04 | 主分类号 | A61K31/445 |
| 代理机构 | Wenderoth, Lind & Ponack, L.L.P. | 代理人 | Wenderoth, Lind & Ponack, L.L.P. |
| 主权项 | 1. A compound represented by the formula (I) wherein is the following formula (a) n is an integer of 2; R1 is —CH2—C(O)—NR3R4; one of R3 and R4 is hydrogen, and the other is lower alkyl; R2 is hydrogen; Ra and Rb are the same or different and each is hydrogen or lower alkyl; X is O; Y is CH2; and Z is CH, or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Osaka JP | ||