Prophylactic agent or therapeutic agent for diabetes or obesity

摘要

A medicament having an excellent CaSR agonist action which enables the prevention or treatment of diabetes or obesity is provided by a composition comprising the compound represented by general formula (I) as defined, or a salt thereof.

主权项

1. A method for treating diabetes or obesity, comprising:
administering to a subject in need thereof, an effective amount of a glutamic acid compound represented by formula (I): wherein R1, R2, R3, R4 and R5 each independently is selected from the group consisting of a hydrogen atom, a halogeno group, a hydroxyl group, a nitro group, an amino group, a C1-6 alkyl group which may have a substituent(s), a C1-6 alkoxy group which may have a substituent(s), a C1-6 mono- or dialkylamino group which may have a substituent(s), a sulfo group, and a group: provided that either one of R1, R2 and R3 is selected from the group consisting of a nitro group, a sulfo group and a group: R6 is a hydrogen atom, a hydroxyl group or a C1-6 alkyl group which may have a substituent(s); R7 is a hydrogen atom or a C1-6 alkyl group which may have a substituent(s); X is a methylene group or an oxygen atom; and, E is a hydroxyl group, a C1-6 alkoxy group which may have a substituent(s), a mercapto group which may have a substituent(s), or a group: wherein Z is selected from the group consisting of a divalent C1-6 hydrocarbon group which may have a substituent(s), and E2 is a hydrogen atom or a C1-6 alkyl group; or a pharmaceutically acceptable salt thereof.