发明名称 |
COMPOSITIONS AND METHODS FOR GENERATING A PERSISTING POPULATION OF T CELLS USEFUL FOR THE TREATMENT OF CANCER |
摘要 |
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells. |
申请公布号 |
KR20140127816(A) |
申请公布日期 |
2014.11.04 |
申请号 |
KR20147021951 |
申请日期 |
2013.02.22 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
FRIGAULT MATTHEW J.;ZHAO YANGBING;SCHOLLER JOHN;JUNE CARL H. |
分类号 |
C12N15/12;A01N63/00;A61K48/00;C07H21/04;C07K14/705;C07K19/00;C12N5/0783;C12N15/62 |
主分类号 |
C12N15/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|