| 摘要 |
Disclosed herein are oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib and a solubility enhancer polymer, processes for preparation of the same and their use as medicaments, more particularly for the treatment of pain. In one embodiment the solubility enhancer polymer is selected from polyvinyl caprolactam-polyvinyl acetatepolyethylene glycol graft copolymer or from copovidone, povidone, cyclodextrin, polyethylene glycol and lauroyl macrogol-32 glycerides EP. |
