Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

摘要

Disclosed herein is a compound of formula (I), wherein the variables are defined in the specification, and the use thereof in the treatment of cancer, a disorder associated with angiogenesis, pain, macular degeneration or a related syndrome, a skin disease, a pulmonary disorder, an asbestos-related disorder, a parasitic disease, an immunodeficiency disorder, a CNS disorder, CNS injury, atherosclerosis or a related disorder, dysfunctional sleep or a related disorder, an infectious disease, hemoglobinopathy or a related disorder or a TNFα related disorder. In one embodiment the compound is 3-(4-(4-(2-morpholinoethoxy)-benzyloxy)-1-oxoisoindolin-2-yl)-piperidine-2,6-dione.