N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

摘要

The disclosure relates to N-hydroxylsulfonamide derivatives represented by the structural formula (III) shown herein, wherein the variables are as defined in the specification. These compounds are suitable for treating, preventing, delaying the onset of, or delaying the development of a disease or condition that is responsive to nitroxyl therapy in an individual in need thereof, wherein the disease or condition is a cardiovascular disease or condition such as heart failure.