| 发明名称 |
Compositions and Methods for Increasing Proliferation of Adult Salivary Stem Cells |
| 摘要 |
The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an indi vidual undergoing radiotherapy for head and neck cancer. |
| 申请公布号 |
US2014323520(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201214110390 |
申请日期 |
2012.04.26 |
| 申请人 |
Chen Che-Hong;Mochly-Rosen Daria;Le Quynh-Thu |
发明人 |
Chen Che-Hong;Mochly-Rosen Daria;Le Quynh-Thu |
| 分类号 |
C07D317/58;C07C233/11;C07D215/24;C07D317/50;C07D235/16 |
主分类号 |
C07D317/58 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of increasing proliferation of adult salivary stem cells, the method comprising contacting adult salivary stem cells in vitro, in vivo, or ex vivo with an effective amount of an aldehyde dehydrogenase (ALDH) agonist selected from an ALDH-1 agonist, an ALDH-3 agonist, and an ALDH 6 agonist, wherein said contacting increases the number of adult salivary stem cells by at least 25%. |
| 地址 |
Fremont CA US |
