| 主权项 |
1. A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein each R1 and each R2 and each R7 is independently selected from the group consisting of hydrogen, halogen, hydroxyl, —CF3, —CN, —(C═O)R8, —O—(C═O)—R8, —(NR8)—(C═O)—R8, —(C═O)—OR8, —(C═O)—N(R8)2, —OR8, —O—(C═O)—OR8, —O—(C═O)—N(R8)2, —NO2, —N(R8)2, —(NR8)—SO2—R8, —S(O)wR8, —SO2—N(R8)2, (C1-C6)alkyl, (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocycloalkyl, and (C3-C10)cycloalkyl; wherein said (C1-C6)alkyl, (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocycloalkyl, or (C3-C10)cycloalkyl are each independently optionally substituted with one, two, three or four R9; w is 0, 1 or 2; m is zero, one, two or three; n is zero, one, two or three; p is zero, one, two or three; q is zero, one, two or three; s is one and t is one; or one of s or t is one and the other of s or t is two; R3 is hydrogen or (C1-C6)alkyl; each R4 is independently selected from hydrogen, or (C1-C6)alkyl; wherein said (C1-C6)alkyl may be optionally substituted with one, two, three or four halogen, —CN, or —OR9; or two R4 groups on the same carbon atom may be taken together to form an oxo (═O) radical or a (C3-C6)spirocycloalkyl; R5 is hydrogen, or (C1-C6)alkyl; R6 is (C1-C6)alkyl-(C═O)—, [(C1-C6)alkyl]2N—(C═O)—, (C1-C6)alkyl-SO2—, (C3-C10)cycloalkyl-SO2—, or [(C1-C6)alkyl]2N—SO2—; wherein said (C1-C6)alkyl moieties of said [(C1-C6)alkyl]2N—(C═O)— and [(C1-C6)alkyl]2N—SO2— may optionally be taken together with the nitrogen atom to which they are attached to form a four to six membered heterocyclic ring; R8 is independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocycloalkyl, and (C3-C10)cycloalkyl; wherein said (C1-C6)alkyl may be optionally substituted with one, two or three substituents independently selected from hydrogen, halo, —CN, perfluoro(C1-C6)alkyl, hydroxy, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, (C1-C6)alkoxy, perfluoro(C1-C6)alkoxy, HO—(C═O)—, (C1-C6)alkyl-O—(C═O)—, formyl, (C1-C6)alkyl-(C═O)—, H2N—(C═O)—, (C1-C6)alkyl]-(NH)—(C═O)—, [(C1-C6)alkyl]2N—(C═O)—, (C1-C6)alkyl-(C═O)—O—, H(C═O)—NH—, (C1-C6)alkyl(C═O)—NH—, (C1-C6)alkyl(C═O)—[N((C1-C6)alkyl)]-, (C1-C6)alkyl-SO2—, (C1-C6)alkyl-SO2—NH—, (C1-C6)alkyl-SO2—[N((C1-C6)alkyl)]-, H2N—SO2—, [(C1-C6)alkyl]-NH—SO2—, and [(C1-C6)alkyl]2N—SO2—; wherein said (C1-C6)alkyl may be additionally optionally substituted with an optionally substituted (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocycloalkyl, or (C3-C10)cycloalkyl; wherein said optional substituents may be independently selected from one, two, three or four radicals independently selected from halogen, hydroxyl, —CF3, —ON, (C1-C3)alkyl, (C1-C3)alkoxy, and amino; wherein each of said R8 (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocycloalkyl or (C3-C10)cycloalkyl substituents may be optionally additionally substituted with one, two, three or four radicals independently selected from halogen, hydroxyl, —CF3, —CN, (C1-C3)alkyl, (C1-C3)alkoxy and amino; each R9 is independently selected from the group consisting of halogen, hydroxyl, —CF3, —CN, —(C═O)R10, —O—(C═O)—R10, —(NR10)—(C═O)—R10, —(C═O)—OR10, —(C═O)—N(R10)2, —OR10, —O—(C═O)—OR10, —O—(C═O)—N(R10)2, —NO2, —N(R10)2, —(NR10)—SO2—R10, —S(O)uR10, —SO2—N(R10)2; R10 is independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocycloalkyl and (C3-C10)cycloalkyl; wherein said (C1-C6)alkyl may be optionally substituted with one, two or three substituents independently selected from hydrogen, halo, —CN, perfluoro(C1-C6)alkyl, hydroxy, amino, (C1-C6)alkylamino, [(C1-C6)alkyl]2amino, (C1-C6)alkoxy, perfluoro(C1-C6)alkoxy, HO—(C═O)—, (C1-C6)alkyl-O—(C═O)—, formyl, (C1-C6)alkyl-(C═O)—, H2N—(C═O)—, (C1-C6)alkyl]-(NH)—(C═O)—, [(C1-C6)alkyl]2N—(C═O)—, (C1-C6)alkyl-(C═O)—O—, H(C═O)—NH—, (C1-C6)alkyl(C═O)—NH—, (C1-C6)alkyl(C═O)—[N((C1-C6)alkyl)]-, (C1-C6)alkyl-SO2—, (C1-C6)alkyl-SO2—NH—, (C1-C6)alkyl-SO2—[N((C1-C6)alkyl)]-, H2N—SO2—, [(C1-C6)alkyl]-NH—SO2—, and [(C1-C6)alkyl]2N—SO2—; wherein said (C1-C6)alkyl may also be additionally optionally substituted with an optionally substituted (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocycloalkyl or (C3-C10)cycloalkyl; wherein said optional substituents may be independently selected from one, two, three or four radicals independently selected from halogen, hydroxyl, —CF3, —CN, (C1-C3)alkyl, (C1-C3)alkoxy, and amino; wherein each of said R10 (C6-C10)aryl, (C1-C9)heteroaryl, (C1-C9)heterocycloalkyl, or (C3-C10)cycloalkyl substituents may be optionally additionally substituted with one, two, three or four radicals independently selected from halogen, hydroxyl, —CF3, —CN, (C1-C3)alkyl, (C1-C3)alkoxy, and amino; R11 is hydrogen or (C1-C6)alkyl; ring “A” is (C6-C10)aryl, (C1-C9)heteroaryl, (C4-C10)cycloalkyl, or (C1-C9)heterocycloalkyl; wherein two of said R1 substituents on said (C4-C10)cycloalkyl and (C1-C9)heterocycloalkyl may optionally be attached to the same carbon atom and may optionally be taken together to be oxo; ring “B” is (C6-C10)aryl, (C1-C9)heteroaryl, (C4-C10)cycloalkyl, or (C1-C9)heterocycloalkyl; “X” is —O— or >C(R4)2; “Y” is absent, >NR11, —(NR11)—(C═O)—, >C═O, —O— or >C(R7)2; and “Z” is —O—, —S—, —(S═O)—, or —(SO2)—. |
