发明名称 |
COMPOSITIONS AND METHODS FOR TREATMENT OF CYTOMEGALOVIRUS |
摘要 |
<p>The present disclosure provides compositions and methods useful for treating HCMV infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (VLPs) which comprise one or more Moloney Murine leukemia virus (MMLV) core proteins and include one or more HCMV epitopes, such as, for example, from HCMV envelope glycoproteins gB and/or gH and/or tegument protein pp65. Among other things, the present invention encompasses the recognition that a combination of antigens (e.g., envelope glycoproteins and structural proteins) can lead to beneficial immune responses, for example that include both a humoral response (e.g., production of neutralizing antibodies) and a cellular response (e.g., T-cell activation).</p> |
申请公布号 |
WO2013068847(A3) |
申请公布日期 |
2014.10.30 |
申请号 |
WO2012IB02854 |
申请日期 |
2012.11.09 |
申请人 |
VARIATION BIOTECHNOLOGIES, INC. |
发明人 |
ANDERSON, DAVID, E.;FLUCKIGER, ANNE-CATHERINE |
分类号 |
C12N15/63;A61K39/245;A61K39/295;A61P31/22;A61P37/04;C07K14/045;C07K14/145;C07K14/15;C07K19/00;C12N7/01;C12N7/04;C12N15/38;C12N15/48;C12N15/62;C12N15/86 |
主分类号 |
C12N15/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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