PARTICLE SIZE REDUCTION OF AN ANTIMUSCARINIC COMPOUND
摘要
The present invention relates to a process for preparing a crystalline micronised particulate of a glycopyrronium salt. The process involves suspending the drug in a water immiscible anti-solvent in which the drug has little or no solubility and micronizing the suspension. The resulting drug particles are physically stable with regard to agglomeration and/or aggregation on storage.
申请公布号
CA2910314(A1)
申请公布日期
2014.10.30
申请号
CA20142910314
申请日期
2014.04.24
申请人
CHIESI FARMACEUTICI S.P.A.
发明人
PASQUALI, IRENE;CASAZZA, ANDREA;SAUNDERS, MARK;LOSI, ELENA