1,4 OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS

摘要

This invention relates to compounds of the formula;;wherein and R1 to R3 are as described herein, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as pharmaceuticals for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

主权项

1. A compound of the formula I wherein R1 is H or F; R2 is C1-7-alkyl; and R3 is —(C═O)—R4 or R5, wherein R4 is heteroaryl substituted by one substituent selected from the group consisting of C3-7-cycloalkyl-C1-7-alkoxy-, C3-7-cycloalkyl-C2-7-alkynyl-, C1-7-alkoxy-C2-7-alkynyl-, unsubstituted heteroaryl, unsubstituted C3-7-cycloalkyl and C1-7-alkyl-S—, or R4 is heteroaryl substituted by one halogen and one amidyl; and R5 is C3-7-cycloalkyl-C1-7-alkyl-; or a pharmaceutically acceptable salt thereof.