The disclosure relates to methods of identifying a compound that comprises an epitope that induces immune tolerance in a patient suffering from an autoimmune disease. The disclosure further relates to methods of treating an autoimmune disease by administering (i) a compound identified by the methods described herein, (ii) regulatory T-cells from the patient or a compatible donor, or (iii) a combination of regulatory T-cells and a compound identified by the methods described herein. The disclosure further relates to methods of treating age-related macular degeneration and uveitis.
申请公布号
WO2014176235(A2)
申请公布日期
2014.10.30
申请号
WO2014US34948
申请日期
2014.04.22
申请人
ENZO BIOCHEM, INC.;NUSSENBLATT, RICHARD;LIU, BAOYING;WEI, LAI;RABBANI, ELAZAR;DONEGAN, JAMES, J.
发明人
NUSSENBLATT, RICHARD;LIU, BAOYING;WEI, LAI;RABBANI, ELAZAR;DONEGAN, JAMES, J.