| 摘要 |
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk). |
| 申请人 |
MERCK SHARP & DOHME CORP.;MERCK CANADA INC.;ANTHONY, NEVILLE, J.;ANDRESEN, BRIAN, M.;NORTHRUP, ALAN, B.;CHILDERS, KALEEN, K.;DONOFRIO, ANTHONY;MILLER, THOMAS, A.;LIU, YUAN;MACHACEK, MICHELLE, R.;WOO, HYUN CHONG;SPENCER, KERRIE, B.;ELLIS, JOHN MICHAEL;ALTMAN, MICHAEL, D.;ROMEO, ERIC, T.;GUAY, DANIEL;GRIMM, JONATHAN;LEBRUN, MARIE-EVE;ROBICHAUD, JOEL, S.;WANG, LIPING;DUBOIS, BYRON;DENG, QIAOLIN |
发明人 |
ANTHONY, NEVILLE, J.;ANDRESEN, BRIAN, M.;NORTHRUP, ALAN, B.;CHILDERS, KALEEN, K.;DONOFRIO, ANTHONY;MILLER, THOMAS, A.;LIU, YUAN;MACHACEK, MICHELLE, R.;WOO, HYUN CHONG;SPENCER, KERRIE, B.;ELLIS, JOHN MICHAEL;ALTMAN, MICHAEL, D.;ROMEO, ERIC, T.;GUAY, DANIEL;GRIMM, JONATHAN;LEBRUN, MARIE-EVE;ROBICHAUD, JOEL, S.;WANG, LIPING;DUBOIS, BYRON;DENG, QIAOLIN |
