Novel Formulations which Stabilize and Inhibit Precipitation of Immunogenic Compositions

摘要

C NRPonbN)CCRXS/457I05_I.DOC-I AIK2012 The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like. WO 2007/127665 PCTIUS2I)07/066959 CI-4 O CI C14, CL l~t C .'DI LL-=o 0) V)LLL LO r N y