TREATMENTS FOR GASTROINTESTINAL DISORDERS

摘要

The present invention provides new uroguanylin derivatives that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.

主权项

1. A polypeptide comprising the amino acid sequence:
Xaa1-Xaa2-Xaa3-Cys4-Xaa5-Xaa6-Cys7-Xaa8-Xaa9-Xaa10-Ala11-Cys12-Xaa13-Xaa14-Cys15-Xaa16-Xaa17-Xaa18 [SEQ ID NO: 22] wherein Xaa1 is Gly, Asn, Pro, Gln, Ser, Thr, Ala, Val, Leu, Ile, Met, Phe, Trp, Tyr or is absent; Xaa2 is Asp, Glu, Gly, His, Asn, Ser, Gln, Thr or is absent; Xaa3 is Thr, Glu, Asp, or Ser; Xaa5 is P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, P-homo-Thr, P-Cys or P-Tyr Xaa6 is Ile or Leu; Xaa8 is Val, Ile, Ala, or Leu; Xaa9 is Asn, Tyr, Phe, or Gln; Xaa10 is Val, Ile, Ala, Leu or Pro; Xaa13 is Ala, Ser or Thr; Xaa14 is Gly or Ala; Xaa16 is Leu, Ile, Phe, Trp, Tyr, or is absent; Xaa17 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, Tyr, Asp, Glu, Gln, Asn or is absent; and Xaa18 is Arg, Lys, Ala, Leu, Val, Ile, Ser, Thr, Met, Phe, Trp, Tyr, Asp, Glu, Gln, Asn or is absent.