| 摘要 |
<p>PURPOSE: A capacity decision method of blood flow dependability drug for liver disease treatment is provided to be the index of necessary capacity determination according to the severity of liver disease and get the most reasonable AUC and Cmax value. CONSTITUTION: A capacity decision method of blood flow dependability drug according to the severity of liver disease is provided to use AUC(Area under the plasma concentration-time curve) and Cmax as an index. The AUC value is drawn by the equation 1.[Equation 1]F (AUC) = 591.3+349.9*H / L ratio-0.345*AST-0.892*ALT-39.45 * (AST/ALT ratio) +0.172*LDH. H/L ration is the rate of heart/ liver as a hepatic portal vein index, ALT(Alanine transaminase) and AST(Aspartic acid transaminase) are blood serum brine value, and LDH is lactate dehydrogenase value. [Reference numerals] (AA) First group; (BB) Second group; (CC) Third group</p> |
