| 发明名称 |
PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF |
| 摘要 |
The present invention relates to the use of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, solids forms, and pharmaceutical compositions thereof for the treatment of CFTR mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations. |
| 申请公布号 |
US2014323521(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201414268506 |
申请日期 |
2014.05.02 |
| 申请人 |
Vertex Pharmaceuticals Incorporated |
发明人 |
Van Goor Fredrick F.;Burton William Lawrence;Huang Chien-Jung;Negulescu Paul Adrian;Yu Haihui |
| 分类号 |
C07D215/233 |
主分类号 |
C07D215/233 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cystic fibrosis in a human, wherein the method comprises administering N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) to a patient possessing one human CFTR mutation selected from K1060T and A1067T. |
| 地址 |
Boston MA US |
