HETEROCYCLIC COMPOUNDS AND USES THEREOF

摘要

Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

主权项

1. A method of preparing a compound of Formula A: comprising the steps of: a) reacting a compound of Formula A1 with a compound of Formula B1: to result in a compound of Formula C1: b) converting the compound of Formula C1 to a compound of Formula D1: c) reacting the compound of Formula D1 with a compound of Formula E1: and to result in a compound of Formula A; wherein: X1 is Br or I; X2 is Br, Cl or I; one of Wc and Wd is N, and the other is O, NR10, or S; n is 1, 2, or 3; G is hydrogen, alkyl, alkenyl or aryl; or the G groups of  join together to form a 5- or 6-membered cyclic moiety; and R1 and R2 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocycloalkyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxy, nitro, phosphate, urea, carbonate, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety.