Therapies for Disorders of the Cornea and Conjunctiva

摘要

Unexpectedly, disorders of the cornea and conjunctiva are found to be caused or to be exacerbated, at least in part, by extracellular ATP and P2X7 receptor activation. Therapeutic compositions for topical administration to the eye for the treatment of disorders of the cornea and conjunctiva include an entity that inhibits P2X7 receptor function, reduces the effective concentration of extracellular ATP, or both.

主权项

1. A composition for application to an eye comprising an irreversible P2X7 inhibitor, oxATP, or a chemical derivative of oxATP that is an irreversible P2X7 inhibitor, and an ophthalmically acceptable formulation.