| 发明名称 |
NANOPORE DEVICE FOR DRUG-LIKE MOLECULE SCREENING OR LEAD OPTIMIZATION TO A TARGETED PROTEIN |
| 摘要 |
A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged molecule to pass but to block a protein molecule attached to a ligand connecting to the charged molecule, the opening being filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged molecule through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged molecules passing into the opening. The current changes are employed to trigger a bias field increase to cause separation between the ligand and the protein to infer an interaction strength. |
| 申请公布号 |
US2014318970(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201313966628 |
申请日期 |
2013.08.14 |
| 申请人 |
International Business Machines Corporation |
发明人 |
LUAN BINQUAN;ZHOU RUHONG |
| 分类号 |
G01N27/447 |
主分类号 |
G01N27/447 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nanosensor for detecting molecule characteristics, comprising:
a membrane having an opening configured to permit a charged molecule to pass but to block a protein molecule attached to a ligand connecting to the charged molecule, the opening being filled with an electrolytic solution; an electric field generator configured to generate an electric field relative to the opening to drive the charged molecule through the opening; and a sensor circuit coupled to the electric field generator to sense current changes due to charged molecules passing into the opening, the current changes being employed to trigger a bias field increase to cause separation between the ligand and the protein molecule to infer an interaction strength. |
| 地址 |
Armonk NY US |
