| 主权项 |
1. A compound of formula (I) or a pharmaceutically acceptable ester, amide, carbamate or salt thereof, including a salt of such an ester, amide or carbamate in which R1 is selected from the group consisting of optionally substituted 5-10 membered heterocyclyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted C3-8cycloalkyl, optionally substituted C5-6cycloalkenyl, optionally substituted phenylC2-4alkenyl, C2-8alkenyl, haloC2-8alkenyl, dihaloC2-8alkenyl, trihaloC2-8alkenyl, and C3-8cycloalkylC2-4alkenyl, wherein when said heterocyclyl, phenyl or naphthyl group or part of group is substituted, it is substituted with from 1 to 5 substituents, each substituent being independently selected from the group consisting of ORA, N(RB)2, halogen, cyano, nitro, —C(O)C1-4alkyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6 alkyl, dihaloC1-6alkyl and trihaloC1-6alkyl, and when said C3-8cycloalkyl or C5-6cycloalkenyl group is substituted, it is substituted with 1, 2 or 3 substituents selected from C1-5alkyl, C1-5alkenyl, C1-5alkynyl, C1-5alkyl substituted with up to 3 halogen atoms, —CO—C1-5alkyl, and halogen; R2 is selected from the group consisting of —C(NH2)═N—OH, —C(O)N(RC)2, cyano, —CHO, —CH═N—OH, —C(O)NH—OH, —C(CO2H)═N—OH, —C(O—C1-4alkyl)=NH, —C(NH2)═N—NH2, —C(O)—C(O)—NH2, —C(O)CO2H, —CO2H, —CH2—CO2H, —CH(OH)CO2H, —C H2NH—CONH2, C1-6alkyl-NH2, C1-6alkyl-OH, —CH2SO3H, —NH—C(NH2)═NH, —NH—C(O)NH2, —N═C(—NH—CH2CH2—NH—), N(RB)2, N(OH)2, NHSO2RD, —S—CN, —S—C(NH2)═NH, —S—C(NH2)═N—OH, SO2N(RE)2, SO3H, cyanoC1-6alkyl, and optionally substituted 5-10 membered heterocyclyl containing from one to three nitrogen atoms, wherein when said heterocyclyl group is substituted, it is substituted with from 1 to 3 substituents, each substituent being independently selected from the group consisting of ORA, N(RB)2, halogen, cyano, nitro, —C(O)C1-4alkyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6 alkyl, dihaloC1-6alkyl and trihaloC1-6alkyl; R3 is selected from the group consisting of hydrogen, halogen, cyano, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, haloC1-6alkyl, dihaloC1-6alkyl, trihaloC1-6alkyl, optionally substituted phenyl, optionally substituted phenylC1-4alkyl, optionally substituted 5-10 membered heterocyclyl, and optionally substituted 5-10 membered heterocyclylC1-4alkyl, wherein when said phenyl or heterocyclyl group or part of group is substituted, it is substituted with from 1 to 5 substituents, each substituent being independently selected from the group consisting of ORA, N(RB)2, halogen cyano, nitro, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6alkyl, dihaloC1-6alkyl and trihaloC1-6alkyl; R4 is selected from the group consisting of hydrogen, halogen, cyano, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, and haloC1-6alkyl, dihaloC1-6alkyl, and trihaloC1-6alkyl; each of R5, R6, R8 and R9 is independently selected from the group consisting of hydrogen, ORA, N(RB)2, halogen, cyano, nitro, —C(O)C1-4alkyl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6 alkyl, dihaloC1-6alkyl and trihaloC1-6alkyl; R7 is ORA; or R6 and R7 may, together with the atoms they are attached to, form a 5-, 6- or 7-membered cyclic group optionally containing one to three heteroatoms selected from O, N and S, said 5-, 6- or 7-membered cyclic group being optionally substituted with one of more groups selected from ORA, cyano, nitro, C1-6 alkyl, C2-6alkenyl, C2-6alkynyl, halo C1-6 alkyl, dihalo C1-6 alkyl and trihalo C1-6 alkyl; and each RA, each RB, each RC, each RD and each RE is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl and C3-8cycloalkylC1-6alkyl; each optionally substituted by from 1 to 3 halogen atoms. |
