NITROGEN MUSTARD DERIVATIVES, METHOD OF PREPARING SAME, AND TUMOR TREATMENT APPLICATION

摘要

A new nitrogen mustard derivative of Formula I or a pharmaceutically acceptable salt thereof, where R is N(CH2CH2Cl)2. Experiments show that the compound can inhibit a phase of the cell in Phase G2/M and is a dual-function alkylating agent. In vivo antitumor activity experiments show that the compound has desirable activity. Moreover, this compound further has advantages that nitrogen mustard drugs do not, that is, low toxicity. Also, this compound is easy to synthesize and has a high total yield. These advantages show that this compound has a great potential to be used as tumor treatment drugs.