发明名称 |
Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same |
摘要 |
<p>Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed that comprise the sequences that encodes consensus RSV F protein or immunogenic fragment thereof, sequences that encodes an RSV G(A) protein or immunogenic fragment thereof and sequences that encodes an RSV G(B) protein or immunogenic fragment thereof. Compositions comprising one, combinations of two or all three sequences are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Nucleic acid molecules and compositions comprising the chemokine CC20 and/or a consensus RSV M2-1 protein or immunogenic fragment thereof are also disclosed. Immunomodulatory methods and methods of inducing an immune response against RSV are disclosed. Method of preventing RSV infection and methods of treating individuals infected with RSV are disclosed.</p> |
申请公布号 |
AU2013245950(A1) |
申请公布日期 |
2014.10.30 |
申请号 |
AU20130245950 |
申请日期 |
2013.04.10 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
WEINER, DAVID B.;CHOO, DANIEL;MUTHUMANI, KARUPPIAH;OBENG-ADJEI, NYAMEKYE;SCOTT, VERONICA |
分类号 |
C07K14/135 |
主分类号 |
C07K14/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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