| 发明名称 |
CHANNELRHODOPSINS FOR OPTICAL CONTROL OF CELLS |
| 摘要 |
The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels. |
| 申请公布号 |
US2014324134(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201214357635 |
申请日期 |
2012.11.12 |
| 申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY ;THE GOVERNORS OF THE UNIVERSITY OF ALBERTA |
发明人 |
Klapoetke Nathan;Chow Brian Yichiun;Boyden Edward;Wong Gane Ka-Shu;Cho Yongku Peter |
| 分类号 |
C12N13/00;G01N33/487;A61N5/06;C07K14/405 |
主分类号 |
C12N13/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of altering ion conductivity of a membrane, the method comprising,
a) expressing in a host membrane a light-activated ion channel polypeptide comprising an amino acid sequence of a wild-type or modified light-activated Chlamydomonas noctigama, Stigeoclonium helveticum, or Chloromonas subdivisa polypeptide, and b) contacting the light-activated ion channel polypeptide with a light that activates the light-activated ion channel and alters the ion conductivity of the membrane. |
| 地址 |
Cambridge MA US |
