| 发明名称 |
POPULATIONS OF HEMATOPOIETIC PROGENITORS AND METHODS OF ENRICHING STEM CELLS THEREFOR |
| 摘要 |
There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of CD43 and at least one of CD34, CD31 and CD144; and selecting a fraction that is at least one of CD34+CD43−, CD31+CD43− and CD144+CD43−. Also provided are populations of hematopoietic progenitors obtained by the methods described herein. |
| 申请公布号 |
US2014322808(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201214359517 |
申请日期 |
2012.11.21 |
| 申请人 |
University Health Network ;Sunnybrook Research Institute |
发明人 |
Keller Gordon;Zuniga-Pflucker Juan Carlos;Kennedy Marion J.;Sturgeon Christopher Michael;Ditadi Andrea;Awong Geneve Sheandra |
| 分类号 |
C12N5/0789 |
主分类号 |
C12N5/0789 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of enriching a population of stem cells for hematopoietic progenitors, the method comprising:
a. inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; b. sorting the population based on expression of CD43 and at least one of CD34, CD31 and CD144; and c. selecting a fraction that is at least one of CD34+CD43−, CD31+CD43− and CD144+CD43−. |
| 地址 |
Toronto CA |
