NEUROPEPTIDE Y OVEREXPRESSION FOR USE IN THE TREATMENT OF PREMATURE AGING

摘要

The present application describes the therapeutic effect of hypothalamic neuropeptide Y overexpression against age related pathologies progression and progeroid syndromes, namely the Hutchinson-Gilford progeria syndrome. The application also describes the use of the hypothalamic neuropeptide Y overexpression in the treatment of genetic or acquired lipodystrophies, such as selective loss of body fat, anorexia and cachexia, or in the treatment of alopecia, early hair loss, subcutaneous fat loss, bone dysfunction and recognition memory.