COMBINATION COMPOSITIONS AND METHODS OF TREATMENT

摘要

The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating cellular proliferation processes, and methods of treating disease, disorders, and symptoms thereof.

主权项

1. A method for treating a disease or disorder in a subject, comprising administering to the subject a glucocorticoid compound and a compound according to Formula I: wherein:
each R is independently H or optionally substituted alkyl;each R1 is independently H, or optionally substituted alkyl;each R2 is independently H, optionally substituted alkyl, or C(O)R;each R3 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;each R4 is independently H, optionally substituted alkyl, C(O)OR, or C(O)NRR;
and pharmaceutically acceptable salts, solvate, or hydrate thereof.