Human progenitor T-cells

摘要

Human progenitor T cells that are able to successfully engraft a murine thymus and differentiate into mature human T and NK cells are described The human progenitor T cells have the phenotype CD34+CD7+CD 1a-CD5- or CD34+CD7+CDla-CD5+ and are derived from human hematopoietic stem cells, embryonic stem cells and induced pluripotent stem cells b/ coculture with cells expressing a Notch receptor ligand (OP9-DL1 or OP9-DL4) Such cells are useful in a variety of applications including immune reconstitution, the treatment of immunodeficiencies and as carriers for genes used in gene therapy.