| 摘要 |
<p>The present invention relates to spirocyclic acylguanidines and their use as inhibitors of theβ-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production ofβ-amyloid aggregates.</p> |
| 申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;VITAE PHARMACEUTICALS, INC. |
发明人 |
BUKHTIYAROV, YURI;CACATIAN, SALVACION;DILLARD, LAWRENCE, WAYNE;DORNER-CIOSSEK, CORNELIA;FUCHS, KLAUS;JIA, LANQI;LALA, DEEPAK, S.;MORALES-RAMOS, ANGEL;RAST, GEORG;REEVES, JONATHAN;SINGH, SURESH, B.;VENKATRAMAN, SHANKAR;XU, ZHENRONG;YUAN, JING;ZHAO, YI;ZHENG, YAJUN |
