The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and/or hyperphosphorylated tau. The invention is also directed to use of the compounds as O-GlcNAcase imaging agents.
申请公布号
AU2013259892(A1)
申请公布日期
2014.10.30
申请号
AU20130259892
申请日期
2013.05.03
申请人
MERCK SHARP & DOHME CORP.;ALECTOS THERAPEUTICS INC.
发明人
SELNICK, HAROLD G.;LI, WENPING;HOSTETLER, ERIC;LIU, KUN;MCEACHERN, ERNEST J.;ZHOU, YUANXI;WEI, ZHONGYONG;MU, CHANGWEI;WANG, YAODE;CHANG, JIANG