摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for manufacturing granules that mask a physiologically active substance having bitterness and have improved oral administration of a patient by a simple method having high safety. <P>SOLUTION: Microparticles (fine particles) that guarantee light stability and mask bitterness are produced by feeding additive powder particles to a jet fluidized bed granulator, spraying a liquid in which donepezil hydrochloride is dispersed, suspended or partially dissolved in an aqueous solution of polymer binder to the particles while keeping a fluidized state to prepare nuclear particles (granules), spraying a liquid in which insoluble additive particles dispersed or suspended in an aqueous solution of a polymer binder is wet ground to the surfaces of the nuclear particles to form a barrier layer and then coating the particles with a membrane agent for elution control. Further the obtained microparticles are mixed with another additive, regranulated and then tableted to produce high-quality tablets quickly disintegrable in oral cavity, which guarantee light stability and have superior oral administration. <P>COPYRIGHT: (C)2012,JPO&INPIT</p> |