发明名称 |
DETECTION AND TREATMENT OF BREAST CANCER |
摘要 |
The present invention describes methods for determining the risk that a breast precursor lesion will progress to invasive breast cancer and/or the risk of recurrent non-invasive disease in a patient, comprising detecting the presence and/or level of PAPPA and/or PAPPA functional activity in a breast tissue sample obtained from the patient, wherein if PAPPA is not present, or is present at a reduced amount compared to a control, there is the risk of progression to invasive cancer and/or the risk or recurrent disease. The present invention also enables the chemosensitisation of mitotically delayed breast cancer cells to anti-proliferative agents, preferably anti-mitotic agents, by restoring normal progression through mitosis. In this embodiment a first drug is applied to release breast cancer cells from the mitotic block and, sequentially, a second drug affecting proliferating cells is administered for cancer cell killing. |
申请公布号 |
EP2795331(A2) |
申请公布日期 |
2014.10.29 |
申请号 |
EP20120813943 |
申请日期 |
2012.12.20 |
申请人 |
THE EUROPEAN MOLECULAR BIOLOGY LABORATORY;UCL BUSINESS PLC.;FAHY GURTEEN LABORATORIES LTD. |
发明人 |
ELLENBERG, JAN;NEUMANN, BEATE;LODDO, MARCO;WILLIAMS, GARETH;STOEBER, KAI;VELAMAKANNI, SAROJ |
分类号 |
G01N33/574;A61K38/17;C07K14/47;C12Q1/68 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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