摘要 |
<p>The present invention provides, among oilier things, compositions and methods for CNS delivery of lysosomal enzymes (e.g., recombinant human arylsulfatase A (rhASA)) for effective treatment of lysosomal storage diseases (e.g. Metachromatic Leukodystrophy Disease). In some embodiments, the present invention includes a stable formulation for intrathecal administration comprising an ASA protein and a poloxamer, wherein less than 3% of the ASA protein exists in aggregated form.</p> |
申请人 |
SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
SALAMAT-MILLER, NAZILA;TAYLOR, KATHERINE;CAMPOLIETO, PAUL;SHAHROKH, ZAHRA;PAN, JING;CHARNAS, LAWRENCE;WRIGHT, TERESA, LEAH;CALIAS, PERICLES;JAIN, KEETHKUMAR;BASU, SUJIT |