| 发明名称 |
SINGLE DOMAIN ANTIBODIES AS INHIBITORS OF PCSK9 |
| 摘要 |
<p>Antibodies (e.g., sdAbs) binding to PCSK9 are described. Nucleic acids encoding such Abs, host cells expressing such Abs and pharmaceutical composition comprising same are described. The use of these PCSK9-binding Abs for lowering low-density lipoprotein-cholesterol (LDL-C) levels and for the treatment of cardiovascular disorders, is also described.</p> |
| 申请公布号 |
EP2794661(A1) |
申请公布日期 |
2014.10.29 |
| 申请号 |
EP20120859390 |
申请日期 |
2012.12.20 |
| 申请人 |
ADAERATA, LIMITED PARTNERSHIP;NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
SEIDAH, NABIL G.;ZHANG, JIANBING |
| 分类号 |
C07K16/40;A61K39/395;A61P3/06;C12N15/13;G01N33/573 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
